[Ginkgo biloba extracts (EGb761) inhibits aflatoxin B1-induced hepatocarcinogenesis in Wistar rats].
Zhong Yao Cai
; 32(1): 92-6, 2009 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-19445131
ABSTRACT
OBJECTIVE:
To investigate the effect of Ginkgo biloba extracts (EGb761) on aflatoxin B1 (AFB1)-induced hepatocarcinogenesis and its antioxidant activity in Wistar rats.METHODS:
71 Wistar rats were randomly divided into three groups AFB1 (group A); AFB1 +EGb761 (group B), Control (group C). Rats in gurop A and B were injected with AFB, through abdomen and the doses were 100-200 microg/kg, one to three times a week. Liver biopsy were performed in all rats during 14th w, 28th w, 42th w and 55th w, and were executed at 64th w. Gammaglutamyl transpeptidase-positive hyperplastic cell foci (gamma-GT foci) and histopathology of the liver tissue were observed. The levels of malondialdehyde (MDA), as well as the activity of Glutathione peroxidase (GSH-Px) was examined.RESULTS:
At 42th w and 55th w, the gamma-GT focus area (mm2/focus) and general area of foci (mm2/cm2) of group B were significantly smaller than that in group A (P = 0.000). The incidence of hepatocelluiar carcinoma (HCC) in group B (26.92%) was significantly lower than that in group A(76%) (P = 0.000). Group C didnt have HCC development. EGb 761 markedly increased GSH-Px activity, reduced MDA levels (P < 0.05).CONCLUSION:
EGB761 shows effective inhibition to hepatocarcinogenesis induced by AFB1 in rats, which may be related to its antioxidant activity.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Ginkgo biloba
/
Neoplasias Hepáticas Experimentais
/
Antioxidantes
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article