Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine-resistant isolates from the Brazilian Amazon region.
Antimicrob Agents Chemother
; 53(8): 3561-4, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19451296
ABSTRACT
Plasmodium vivax parasites with chloroquine resistance (CQR) are already circulating in the Brazilian Amazon. Complete single-nucleotide polymorphism (SNP) analyses of coding and noncoding sequences of the pvmdr1 and pvcrt-o genes revealed no associations with CQR, even if some mutations had not been randomly selected. In addition, striking differences in the topologies and numbers of SNPs in these transporter genes between P. vivax and P. falciparum reinforce the idea that mechanisms other than mutations may explain this virulent phenotype in P. vivax.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Plasmodium vivax
/
Resistência a Medicamentos
/
Proteínas de Protozoários
/
Cloroquina
/
Polimorfismo de Nucleotídeo Único
/
Proteínas Associadas à Resistência a Múltiplos Medicamentos
Limite:
Animals
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article