The impact of statins, ACE inhibitors and gastric acid suppressants on pneumonia mortality in a UK general practice population cohort.
Pharmacoepidemiol Drug Saf
; 18(8): 697-703, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19455553
ABSTRACT
BACKGROUND:
Pneumonia is a common diagnosis in general practice in the United Kingdom. Previous studies suggest that commonly prescribed drugs in general practice may influence pneumonia mortality.AIM:
We investigated whether statins, angiotensin converting enzyme inhibitors (ACEIs), proton pump inhibitors (PPIs) and histamine-2-receptor antagonists (H(2)RAs) have an impact on short-term and long-term mortality in pneumonia cases. DESIGN OF STUDY Population-based cohort study SETTTING United KingdomMETHODS:
Data on 3681 pneumonia cases above the age of 40 years were obtained from a comprehensive database called the health improvement network (THIN) which has computerised medical records from 300 general practice surgeries in the United Kingdom. We used Cox regression for our analyses.RESULTS:
Current statin use was associated with a 67% decrease in 30-day mortality (adj. HR 0.33, 95% CI 0.19-0.58) and a 55% decrease in long-term mortality (adj. HR 0.45, 95% CI 0.32-0.62) over a median follow-up of 2.8 years as compared to no-use. Current ACEI use decreased the 30-day mortality risk by nearly 38% as compared to no-use (adj. HR 0.62, 95% CI 0.47-0.82) but was not associated with long-term mortality. No significant impact on mortality was observed for either gastric acid suppressant.CONCLUSION:
The use of statins is associated with a lower risk of short- and long-term mortality following pneumonia whereas the use of ACEIs is associated with a decreased mortality risk only in the short-term.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
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Inibidores da Enzima Conversora de Angiotensina
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Inibidores de Hidroximetilglutaril-CoA Redutases
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Inibidores da Bomba de Prótons
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Medicina de Família e Comunidade
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Antagonistas dos Receptores H2 da Histamina
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Female
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Humans
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Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article