Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings.
Org Lett
; 11(11): 2257-60, 2009 Jun 04.
Article
em En
| MEDLINE
| ID: mdl-19473044
ABSTRACT
A regioselective intramolecular Huisgen cycloaddition was performed on various azido alkyne substrates giving rise to macrocyclic triazole rings. Using catalyst control, a common intermediate has been converted to two structurally unique macrocycles with either a 1,5- or a 1,4-triazole resulting in an n or n + 1 ring size. This is the first example of an intramolecular ruthenium-catalyzed Huisgen cycloaddition.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rutênio
/
Triazóis
/
Alcinos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article