Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction.
Clin Nephrol
; 71(5): 567-70, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19473619
ABSTRACT
We describe an HIV1-positive patient under long-term tenofovir treatment who developed a severe, biopsy-proven, acute tubular necrosis with proximal tubule (PT) dysfunction, precipitated by the very recent start of diclofenac, a nonsteroidal antiinflammatory drug (NSAID). Recent studies show that NSAIDs not only alter glomerular filtration but also multidrug resistance protein (MRP) 4-mediated PT secretion of several substrates. Since the patient tolerated tenofovir well for several years prior to diclofenac use, our observation suggests that diclofenac interfered with tenofovir clearance, thereby favoring its nephrotoxicity. NSAIDs should be avoided in patients under tenofovir.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Adenina
/
Anticorpos Anti-HIV
/
Diclofenaco
/
HIV-1
/
Soropositividade para HIV
/
Síndrome de Fanconi
/
Injúria Renal Aguda
/
Organofosfonatos
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article