Immune status, latent viral reactivation, and stress during long-duration head-down bed rest.
Aviat Space Environ Med
; 80(5 Suppl): A37-44, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19476168
ABSTRACT
INTRODUCTION:
As logistical access for space research becomes more limited and NASA prepares for exploration-class missions, ground-based spaceflight analogs will increase in importance for biomedical countermeasures development. A monitoring of immune parameters was performed during the NASA Flight Analogs Project bed rest study (without countermeasure); to establish 'control' data against which future studies (with countermeasure) will be evaluated. Some of the countermeasures planned to be evaluated in future studies may impact immune function.METHODS:
The immune assessment consisted of leukocyte subset distribution, early T cell activation, intracellular cytokine profiles, latent viral reactivation, virus specific T cell levels and function, stress hormone levels, and a behavioral assessment using stress questionnaires.RESULTS:
In general, subjects did not display altered peripheral leukocyte subsets, constitutive immune activation, altered T cell function, or significant latent viral reactivation (EBV, VZV). Levels of constitutively activated T cells (CD8+/CD69+) and virus-specific T cells (CMV and EBV) decreased during the study. Cortisol levels (plasma and saliva) did not vary significantly during 90-d bed rest.CONCLUSIONS:
These data demonstrate the absence of significant immune system alteration and physiological stress during 90-d bed rest, and establish control data against which future studies (including countermeasures) may be compared.
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Base de dados:
MEDLINE
Assunto principal:
Voo Espacial
/
Estresse Fisiológico
/
Repouso em Cama
/
Viroses
/
Decúbito Inclinado com Rebaixamento da Cabeça
/
Sistema Imunitário
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article