Potent agonists of the Hedgehog signaling pathway.
Bioorg Med Chem Lett
; 19(15): 4308-11, 2009 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-19500978
ABSTRACT
A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to substitution on the 4-amino group, and SAR for the 3-chlorobenzothiophene group is highly specific. Preliminary SAR studies of the biaryl substituent led to a picomolar compound with in vivo activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Carboxílicos
/
Química Farmacêutica
/
Proteínas Hedgehog
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article