Antithrombogenic and antiplatelet activities of extract from Maackia amyrensis wood.
Bull Exp Biol Med
; 147(2): 204-7, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19513422
ABSTRACT
Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. The reference drug ethinylestradiol (25 mug/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Vasodilatação
/
Coagulação Sanguínea
/
Inibidores da Agregação Plaquetária
/
Extratos Vegetais
/
Maackia
/
Fibrinolíticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article