Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
J Med Chem
; 52(14): 4111-4, 2009 Jul 23.
Article
em En
| MEDLINE
| ID: mdl-19522500
ABSTRACT
Long chain fatty acid elongase 6 (ELOVL6) catalyzes the elongation of long chain fatty acyl-CoAs and is a potential target for the treatment of metabolic disorders. The ultrahigh throughput screen of our corporate chemical collections resulted in the identification of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of ELOVL6 inhibitor 1a. Optimization of lead 1a led to the identification of the potent, selective, and orally available ELOVL6 inhibitor 1w.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetiltransferases
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Sulfonas
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Tropanos
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Inibidores Enzimáticos
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Octanos
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article