Highly diastereoselective domino synthesis of 6-spirosubstituted pyrido[2,3-d]pyrimidine derivatives in water.
J Comb Chem
; 11(4): 612-6, 2009.
Article
em En
| MEDLINE
| ID: mdl-19537742
ABSTRACT
A highly diastereoselective domino reaction of 2,6-diaminopyrimidine-4-one with structurally diverse aryl aldehydes and various barbituric acids in water under microwave irradiation is described. The products are 6-spiro-substituted pyrido[2,3-d]pyrimidines with high diastereoselectivities (up to 99 1) in which the major diastereomer bears a cis relationship between substituents at the 5- and 7-positions. Furthermore, the mechanism for diastereoselectivity was confirmed by DFT (B3LYP) calculations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Compostos de Espiro
/
Água
/
Técnicas de Química Combinatória
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article