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Primary atherothrombotic occlusive vascular events in premenopausal women with history of adverse pregnancy outcome.
Ben-Ami, S; Oron, G; Ben-Haroush, A; Blickstein, D; Hod, M; Bar, J.
Afiliação
  • Ben-Ami S; Perinatal Division, The Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Thromb Res ; 125(2): 124-7, 2010 Feb.
Article em En | MEDLINE | ID: mdl-19540573
OBJECTIVE: To determine if adverse pregnancy outcomes are associated with atherothrombotic occlusive vascular disease (AOVD) in premenopausal women. DESIGN: Retrospective matched case-control study. SETTING: Tertiary, university-affiliated medical center. POPULATION: Women aged less than 50 years treated for an AOVD (primary cerebrovascular, myocardial, or peripheral arterial ischemic event) from 1995 to 2004. METHOD: The files were reviewed for classical risk factors for AOVD and complications of pregnancy (abortions, pregnancy-induced hypertension, preeclampsia, gestational diabetes, intrauterine growth restriction (IUGR), fetal loss and preterm delivery). Findings were compared with healthy women matched for age and body mass index. MAIN OUTCOME MEASURES: Past pregnancy complications in premenopausal women with AOVD. RESULTS: Of the 101 women with AOVD, 53 had a myocardial ischemic event, 33 a cerebrovascular event, and 15 a peripheral ischemic arterial event. On multivariate analysis, IUGR (OR 8.41, 95% CI 2.36-29.9, p=0.001) and more than one pregnancy complication (OR 13.7, 95% CI 1.56-120, p=0.02) were found to be independent significant variables associated with AOVD. CONCLUSION: IUGR and composite pregnancy complications are independent significant variables associated with AOVD in premenopausal period. Pregnancy outcome might serve as a means to identify patients who may require increased medical surveillance and preventive measures for later vascular disease.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações Cardiovasculares na Gravidez / Trombose / Resultado da Gravidez / Pré-Menopausa / Aterosclerose Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações Cardiovasculares na Gravidez / Trombose / Resultado da Gravidez / Pré-Menopausa / Aterosclerose Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Ano de publicação: 2010 Tipo de documento: Article