Significance of endogenous sulphur-containing gases in the cardiovascular system.
Clin Exp Pharmacol Physiol
; 37(7): 745-52, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-19566822
ABSTRACT
1. The sulphur-containing gases hydrogen sulphide and sulphur dioxide can be generated endogenously in mammalian tissues and exert significant biological effects in the cardiovascular system. Hydrogen sulphide is considered to be the third novel gasotransmitter in addition to nitric oxide and carbon monoxide. The present review describes the effects of hydrogen sulphide on the cardiovascular system and its possible mechanisms under physiological conditions. We also discuss the pathophysiological effects of hydrogen sulphide on cardiovascular diseases. The therapeutic potential of hydrogen sulphide is summarized. 2. We recently discovered that sulphur dioxide, another endogenous sulphur-containing gas, has important physiological and pathophysiological roles in the cardiovascular system. To some extent, the effect of sulphur dioxide is similar to that of the other gasotransmitters nitric oxide, carbon monoxide and hydrogen sulphide. Sulphur dioxide may also be a novel gas mediator in the cardiovascular system.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Óxidos
/
Compostos de Enxofre
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Doenças Cardiovasculares
/
Sulfeto de Hidrogênio
Limite:
Animals
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Humans
/
Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article