The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.
Bioorg Med Chem Lett
; 19(16): 4740-2, 2009 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-19577468
ABSTRACT
A series of tricyclic CGRP receptor antagonists was optimized in order to improve oral bioavailability. Attenuation of polar surface area and incorporation of a weakly basic indoline nitrogen led to compound 5, a potent antagonist with good oral bioavailability in three species.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
/
Antagonistas do Receptor do Peptídeo Relacionado ao Gene de Calcitonina
/
Compostos Heterocíclicos com 3 Anéis
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article