Pediatric cardiac arrest refractory to advanced life support: is there a role for terlipressin?
Pediatr Crit Care Med
; 11(1): 139-41, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19581820
ABSTRACT
OBJECTIVE:
Pediatric cardiac arrest unresponsive to advanced life support and several adrenaline doses has a very poor prognosis. Alternative vasopressors could improve the results of resuscitation in such cases. We report our experience with the compassionate administration of terlipressin in children who suffered in-pediatric intensive care unit cardiac arrest and did not respond to immediate advanced life support and at least three epinephrine doses.DESIGN:
Prospective multicenter registry.SETTING:
Three pediatric intensive care units at university-affiliated tertiary care children's hospitals. PATIENTS Five pediatric patients, aged 5 mos to 12 yrs, with in-pediatric intensive care unit cardiac arrest unresponsive to advanced life support that included at least three epinephrine doses.INTERVENTIONS:
Addition of terlipressin (10-20 microg/kg intravenous, up to two doses) to standard cardiopulmonary resuscitation. MEASUREMENTS AND MAINRESULTS:
Sustained return of spontaneous circulation was achieved in four cases, two of them were declared dead 6 and 12 hrs later, and the remaining two survived without cardiopulmonary procedures-related sequelae and with good neurologic condition.CONCLUSIONS:
Terlipressin might contribute to obtain sustained return of spontaneous circulation in children with refractory in-hospital cardiac arrest. A randomized controlled clinical trial should be conducted to investigate the optimal drug treatment in pediatric cardiac arrest.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vasoconstritores
/
Lipressina
/
Unidades de Terapia Intensiva Pediátrica
/
Suporte Vital Cardíaco Avançado
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article