Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors.
Bioorg Med Chem Lett
; 19(16): 4673-8, 2009 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-19589677
A novel class of imidazopyridine derivatives was designed as PLK1 inhibitors. Extensive SAR studies supported by molecular modeling afforded a highly potent and selective compound 36. Compound 36 demonstrated good antitumor efficacy in xenograft nude rat model.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Proteínas Proto-Oncogênicas
/
Proteínas Serina-Treonina Quinases
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Proteínas de Ciclo Celular
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Inibidores de Proteínas Quinases
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Imidazóis
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Antineoplásicos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article