[Blood coagulation factor levels in candidates for liver transplantation: correlation with disease severity]. / Correlación entre concentraciones de factores de la coagulación en candidatos a trasplante hepático y gravedad de la enfermedad.
Gastroenterol Hepatol
; 32(7): 465-71, 2009.
Article
em Es
| MEDLINE
| ID: mdl-19595482
ABSTRACT
OBJECTIVE:
To correlate blood coagulation factor levels with disease severity in cirrhotic patients evaluated as candidates for liver transplantation. MATERIAL ANDMETHOD:
We included 87 patients (75.9% men) with a mean age of 54+/-9.4 years. Etiology and Child-Turcotte-Pugh (CTP) class were as follows alcohol-related (36.8%), hepatitis C virus infection (35.6%), hepatitis B virus infection (11.5%) and other (16.1%); class A (13.8%), class B (40.2%) and class C (46%), respectively. The mean value of the Model for End-Stage Liver Disease (MELD) score was 14.5+/-5.9. Levels of factors II, V, VII, VIII, IX and X were compared between each CTP grade and with the MELD score.RESULTS:
Except for factor VIII, all the clotting factors were reduced in our series (in particular factors II, V and VII) and deficiencies in these factors were closely related to CTP grade with statistical significance for stage C (p <0.05). We also found a marked inverse correlation between the MELD score and factors II, V, VII, IX and X values (p <0.05).CONCLUSIONS:
A correlation was found between reduced levels of factors II, V, VII, IX and X in liver cirrhosis and the severity of liver disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cuidados Pré-Operatórios
/
Transplante de Fígado
/
Transtornos de Proteínas de Coagulação
/
Hepatopatias
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
Es
Ano de publicação:
2009
Tipo de documento:
Article