A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
Nat Genet
; 41(8): 876-8, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19597491
ABSTRACT
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
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Cromossomos Humanos Par 16
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Isquemia Encefálica
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Proteínas de Homeodomínio
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Predisposição Genética para Doença
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Acidente Vascular Cerebral
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Mutação
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article