Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation.
Nat Struct Mol Biol
; 16(8): 840-6, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19620966
ABSTRACT
Bacterial small noncoding RNAs (sRNAs) generally recognize target mRNAs in the 5' region to prevent 30S ribosomes from initiating translation. It was thought that the mRNA coding sequence (CDS) was refractory to sRNA-mediated repression, because elongating 70S ribosomes have an efficient RNA helicase activity that prevents stable target pairing. We report that the Hfq-associated MicC sRNA silences Salmonella typhimurium ompD mRNA via a
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
RNA Mensageiro
/
Fases de Leitura Aberta
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RNA não Traduzido
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article