Regiospecific and stereoselective syntheses of (+/-) morphine, codeine, and thebaine via a highly stereocontrolled intramolecular 4 + 2 cycloaddition leading to a phenanthrofuran system.
J Am Chem Soc
; 131(32): 11402-6, 2009 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-19624126
ABSTRACT
Total syntheses of the morphine alkaloids are described that use a direct stereoselective formation of the phenanthrofuran system via an intramolecular 4 + 2 cycloaddition of a diene tethered to the 4-position of a 7-methoxybenzofuran-3-carboxylic acid ester.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tebaína
/
Codeína
/
Morfina
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article