Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones.
Bioorg Med Chem Lett
; 19(17): 5060-2, 2009 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-19631536
ABSTRACT
A series of 8-phenylaminopyrimido[4,5-c]isoquinoline-7,10-quinone derivatives were prepared by regioselective amination reaction of pyrimido[4,5-c]isoquinoline-7,10-quinones with arylamines in the presence of a Lewis acid catalyst. Preliminary evaluation of the members of the series against cancer cell lines and assays of activation of their cytotoxic activity on K562 cells with ascorbic acid are reported.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinonas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article