The absorption characteristics of bifendate solid dispersion in rat intestinal tissue.
Drug Dev Ind Pharm
; 36(3): 283-91, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-19663561
ABSTRACT
AIM:
Research on bifendate intestinal absorption.METHOD:
The single passed intestinal backflow method was used. Bifendate with different concentrations, bifendate with and without 2,4-dinitrophenol, verapamil, and probenecid, and solid state of bifendate in different systems were studied.RESULT:
Change of concentration and the presence of energy inhibitor, P-glycoprotein inhibitor and multidrug-resistant protein inhibitor did not affect the K(a) of bifendate intestinal absorption; there were obvious differences among intestinal absorption of native drug, solid dispersion, and physical mixtures.CONCLUSION:
The result indicated that the intestinal absorption mechanism of bifendate is passive transport. Solid state of bifendate in different systems could affect the intestinal absorption.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Bifenilo
/
Absorção Intestinal
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article