[Correlations of chemokine receptor CCR1 expression with metastasis of lymph nodes in colorectal carcinoma tissues].

ABSTRACT

AIM: To investigate the expression of chemokine receptor CCR1 in the human colorectal carcinoma and its correlation with metastasis of lymph nodes. METHODS: By immunohistochemistry, the expression of CCR1 was studied in the colorectal carcinoma of 83 cases and 15 normal cases as control subjects. RESULTS: The positive expression rates of CCR1 in the colorectal carcinoma tissues with deep invasion, poor differentiation, metastasis and higher Dukes' stage were significantly higher than those with superficial invasion (P<0.05), well or moderate differentiation (P<0.05), non-metastasis (P<0.01) and lower Dukes' stage (P<0.05). The LMVD was higher in colorectal carcinoma tissues with positive CCR1 staining than those with negative CCR1 staining (P<0.01). But the MVD had no significantly difference in positive CCR1 staining tissues and negative CCR1 staining tissues. CONCLUSION: The expression of chemokine receptor CCR1 is higher in colorectal carcinoma than normal tissues, and it may correlate with lymph node metastasis.