2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonists.
Bioorg Med Chem Lett
; 19(17): 4916-9, 2009 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-19664922
ABSTRACT
High throughput screening of the corporate compound collection led to the identification of a novel series of 2-amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2',3'4,5]thieno[2,3-b]pyridine derivatives as selective PR agonists. Initial SAR exploration leading to potent and selective agonists 9 and 11, X-ray crystal structure of 9 bound to PR-LBD and preliminary developability data are described.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Piridonas
/
Tiofenos
/
Receptores de Progesterona
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article