Prognostic significance of interleukin-6 single nucleotide polymorphism genotypes in neuroblastoma: rs1800795 (promoter) and rs8192284 (receptor).
Clin Cancer Res
; 15(16): 5234-9, 2009 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-19671870
ABSTRACT
PURPOSE:
Neuroblastoma is a childhood cancer of the sympathetic nervous system and many patients present with high-risk disease. Risk stratification, based on pathology and tumor-derived biomarkers, has improved prediction of clinical outcomes, but overall survival (OS) rates remain unfavorable and new therapeutic targets are needed. Some studies suggest a link between interleukin (IL)-6 and more aggressive behavior in neuroblastoma tumor cells. Therefore, we examined the impact of two IL-6 single nucleotide polymorphisms (SNP) on neuroblastoma disease progression. EXPERIMENTALDESIGN:
DNA samples from 96 high-risk neuroblastoma patients were screened for two SNP that are known to regulate the serum levels of IL-6 and the soluble IL-6 receptor, rs1800795 and rs8192284, respectively. The genotype for each SNP was determined in a blinded fashion and independent statistical analysis was done to determine SNP-related event-free survival (EFS) and OS rates.RESULTS:
The rs1800795 IL-6 promoter SNP is an independent prognostic factor for EFS and OS in high-risk neuroblastoma patients. In contrast, the rs8192284 IL-6 receptor SNP revealed no prognostic value.CONCLUSIONS:
The rs1800795 SNP [-174 IL-6 (G > C)] represents a novel and independent prognostic marker for both EFS and OS in high-risk neuroblastoma. Because the rs1800795 SNP [-174 IL-6 (G > C)] has been shown to correlate with production of IL-6, this cytokine may represent a target for development of new therapies in neuroblastoma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucina-6
/
Receptores de Interleucina-6
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Polimorfismo de Nucleotídeo Único
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Neoplasias do Sistema Nervoso
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Neuroblastoma
Tipo de estudo:
Etiology_studies
/
Evaluation_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article