Calcium-independent membrane damage by venom phospholipases A2.
Protein Pept Lett
; 16(8): 877-86, 2009.
Article
em En
| MEDLINE
| ID: mdl-19689413
ABSTRACT
Many snake venom phospholipase A(2)s (vPLA(2)s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA(2)s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
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Base de dados:
MEDLINE
Assunto principal:
Venenos de Serpentes
/
Serpentes
/
Fosfolipases A2
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article