[Comparison of therapeutic effect of different doses of ganciclovir for neonatal congenital cytomegalovirus infection].
Zhongguo Dang Dai Er Ke Za Zhi
; 11(8): 641-4, 2009 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-19695189
ABSTRACT
OBJECTIVE:
Ganciclovir is a first-line drug for treatment of cytomegalovirus (CMV) infection. However, some ganciclovir treatment-related side-effects can be found. This study aimed to compare the efficacy and side effects of relatively low and high doses of ganciclovir in the treatment of neonatal congenital CMV infection.METHODS:
One hundred and sixty-seven neonates with congenital CMV infection were randomly assigned to high-dose (n=79) and low-dose ganciclovir groups (n=88). The high-dose ganciclovir group was injected with ganciclovir of 7.5 mg/kg in the inducement phase and of 10 mg/kg in the maintaining phase. The low-dose ganciclovir group was injected with ganciclovir of 5 mg/kg in the inducement and the maintaining phases. The efficacy and side effects were observed in the two groups.RESULTS:
After treatment the clinical symptoms and signs were obviously improved in both groups. CMV-IgM became negative in 93.8% of neonates in the high-dose ganciclovir group and 93.1% of neonates in the low-dose ganciclovir group (P>0.05). CMV-DNA became negative in 80.8% of neonates in the high-dose ganciclovir group and in 86.7% in the low-dose ganciclovir group (P>0.05). The low-dose ganciclovir group had lower incidence of side effects than the high-dose ganciclovir group vomiting 2.3% vs 11.4%; anemia 8.0% vs 20.3%; reduction of neutrophilic granulocytes 5.7% vs 16.5%; increase in platelet count 8.0% vs 18.9% (P<0.05).CONCLUSIONS:
Low-dose ganciclovir has the same clinical efficacy to high-dose ganciclovir for treatment of neonatal congenital CMV infection, but fewer side effects occur in the low-dose group.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Ganciclovir
/
Infecções por Citomegalovirus
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article