Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media.
Molecules
; 14(8): 2836-49, 2009 Jul 31.
Article
em En
| MEDLINE
| ID: mdl-19701127
ABSTRACT
Aqueous in situ one-pot N-Boc-deprotection-cyclization of N alpha-Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dicetopiperazinas
/
Micro-Ondas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article