JAK2V617F mutation-positive childhood essential thrombocythemia associated with cerebral venous sinus thrombosis.
J Pediatr Hematol Oncol
; 31(9): 678-80, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19707158
ABSTRACT
Myeloproliferative diseases (MPDs) in childhood are quite rare. Although pediatric and adult MPDs exhibit similar hematologic findings, JAK2V617F mutations and clonality status of MPDs in the DNA of neutrophils are evaluated less frequently in children than in adults. Increased incidence of venous thrombosis at uncommon sites is associated with JAK2V617F mutation in MPDs and thrombotic complications are more common in essential thrombocythemia (ET). Here, we describe 6-year-old girl with clonal myelopoiesis and JAK2V617F-positive ET associated with cerebral venous sinus thrombosis. To our knowledge, this is the first report of pediatric monoclonal and JAK2V617F-positive ET with cerebral venous sinus thrombosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trombose dos Seios Intracranianos
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Janus Quinase 2
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Trombocitemia Essencial
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
Limite:
Child
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Female
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Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article