Fetal effects of psychoactive drugs.
Clin Perinatol
; 36(3): 595-619, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19732616
ABSTRACT
Psychoactive drug use by pregnant women has the potential to effect fetal development; the effects are often thought to be drug-specific and gestational age dependent. This article describes the effects of three drugs with similar molecular targets that involve monoaminergic transmitter systems cocaine, methamphetamine, and selective serotonin re-uptake inhibitors (SSRIs) used to treat maternal depression during pregnancy. We propose a possible common epigenetic mechanism for their potential effects on the developing child. We suggest that exposure to these substances acts as a stressor that affects fetal programming, disrupts fetal placental monoamine transporter expression and alters neuroendocrine and neurotransmitter system development. We also discuss neurobehavioral techniques that may be useful in the early detection of the effects of in utero drug exposure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Psicotrópicos
/
Inibidores Seletivos de Recaptação de Serotonina
/
Cocaína
/
Transtornos Relacionados ao Uso de Substâncias
/
Depressão
/
Desenvolvimento Fetal
/
Feto
/
Metanfetamina
Tipo de estudo:
Screening_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article