Mapping of acute (type I) spinal muscular atrophy to chromosome 5q12-q14. The French Spinal Muscular Atrophy Investigators.
Lancet
; 336(8710): 271-3, 1990 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-1973971
Linkage analysis in twenty-five families with acute (type I) spinal muscular atrophy (SMA) showed that the mutant gene responsible for the disorder is tightly linked to the D5S39 locus. The mutation(s) causing the intermediate (type II) and juvenile chronic (type III) forms of SMA were also mapped to DNA marker D5S39 on chromosome 5 (5q12-q14). Thus, the three forms, which have been differentiated clinically on the basis of age of onset and clinical course, are most probably due to different mutations at a single locus on chromosome 5. Prenatal diagnosis of SMA type I will now be possible.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 5
/
Atrofia Muscular Espinal
/
Mapeamento Cromossômico
/
Mutação
Limite:
Child, preschool
/
Humans
/
Infant
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article