The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior.
Cell Cycle
; 8(19): 3120-4, 2009 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-19755852
ABSTRACT
In response to diverse stresses, the tumor suppressor p53 differentially regulates its target genes, variably inducing cell-cycle arrest, apoptosis or senescence. Emerging evidence indicates that p53 plays an important role in regulating hematopoietic stem cell (HSC) quiescence, self-renewal, apoptosis and aging. The p53 pathway is activated by DNA damage, defects in ribosome biogenesis, oxidative stress and oncogene induced p19 ARF upregulation. We present an overview of the current state of knowledge about p53 (and its target genes) in regulating HSC behavior, with the hope that understanding the molecular mechanisms that control p53 activity in HSCs and how p53 mutations affect its role in these events may facilitate the development of therapeutic strategies for eliminating leukemia (and cancer) propagating cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Proteína Supressora de Tumor p53
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article