Selective destruction of neurons by a transmitter agonist.
Science
; 198(4312): 71-2, 1977 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-197604
ABSTRACT
Microinjection of nanomole amounts of kainic acid, a heterocyclic analog of glutamate, into the cerebellums of adult hamsters and rats causes rapid degeneration of Purkinje, basket, stellate, and Golgi II cells, neurons that receive synaptic input from granule cells, whereas the granule cells themselves are spared. This selectivity is consistent with the evidence that glutamate is the granule cell transmitter and supports the hypothesis that kainic acid exerts its neurotoxic effects through glutamate receptors.
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Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Cerebelo
/
Receptores de Neurotransmissores
/
Glutamatos
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article