Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging.
Biomaterials
; 30(36): 6947-54, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19783295
ABSTRACT
Nanoemulsions are increasingly investigated for the delivery of hydrophobic drugs to improve their bioavailability or make their administration possible. In the current study, oil-in-water emulsions with three different mean diameters (30, 60, and 95 nm) were developed as a new multimodality nanoparticle platform for tumor targeting and imaging. To that aim, hydrophobically coated iron oxide particles were included in the soybean oil core of the nanoemulsions to enable their detection with magnetic resonance imaging (MRI), while the conjugation of a near infrared fluorophore allowed optical imaging. The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex vivo.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Óleos
/
Água
/
Compostos Férricos
/
Emulsões
/
Nanopartículas
/
Neoplasias
Tipo de estudo:
Evaluation_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article