Characterization of endoglin and Ki-67 expression in endothelial cells from benign and malignant lesions of the uterine cervix.
Pathol Int
; 59(10): 695-700, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19788614
ABSTRACT
Activation of endothelial cells is often associated with the cellular proliferation in vitro. CD105 is a more specific marker of activated endothelial cells from tumor vessels and Ki-67 is used to assess the proliferation status of both tumor and endothelial cells. The aim of the present study was to evaluate the status of endothelial cells using CD105 and Ki-67 immunohistochemistry in benign and malignant lesions of the uterine cervix. Double stain for CD105/Ki-67 in benign and malignant lesions of the uterine cervix showed that these two markers had divergent expression on endothelial cells from associated tumor blood vessels dependent on lesion type and proliferation status of tumor cells. Absence of CD105/Ki-67 coexpression in endothelial cells was correlated with histopathology of the uterine cervix lesions and tumor proliferative status. The present findings suggest that CD105 expression is an early event, specific for premalignant lesions of the uterine cervix, while endothelial proliferation assessed on Ki-67 combined with the lack of CD105 expression is often associated with invasive cervical carcinoma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
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Antígenos CD
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Displasia do Colo do Útero
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Neoplasias do Colo do Útero
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Colo do Útero
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Receptores de Superfície Celular
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Antígeno Ki-67
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Células Endoteliais
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article