Protein and energy metabolism in type 1 diabetes.
Clin Nutr
; 29(1): 13-7, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-19788950
ABSTRACT
Profound metabolic changes occur in people with type 1 diabetes mellitus during insulin deprivation. These include an increase in basal energy expenditure and reduced mitochondrial function. In addition, protein metabolism is significantly affected during insulin deprivation. A greater increase in whole-body protein breakdown than protein synthesis occurs resulting in a net protein loss. During insulin deprivation the splanchnic bed has a net protein accretion which accounts for the total increase in whole-body protein synthesis while muscle is in a net catabolic state.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Diabetes Mellitus Tipo 1
/
Metabolismo Energético
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article