Mitogen activated protein kinases: a role in inflammatory bowel disease?
Clin Exp Immunol
; 158(3): 272-80, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19793335
ABSTRACT
Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Proteínas Quinases Ativadas por Mitógeno
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article