Modeling vertical transmission of HIV: imperfect vaccines can be of benefit.
Vaccine
; 27(50): 7003-10, 2009 Nov 23.
Article
em En
| MEDLINE
| ID: mdl-19800442
ABSTRACT
Reducing mother to child transmission (MTCT) of HIV in resource poor countries continues to be a major challenge. Here, we construct a hazard model to assess the effectiveness of combinations of HIV vaccine, Nevirapine (NVP), and HIV-specific monoclonal antibody (HIVAB) in reducing MTCT of HIV during the intrapartum and breastfeeding periods. The model shows that an intervention that uses three doses of vaccine with 30% initial immunity and 30% boost effect with subsequent doses (giving rise to maximum immunity approximately 66% with 3 doses) could reduce MTCT to 7.7% when used with NVP and to 5.9% when used with NVP and HIVAB. Using a vaccine with 50% initial immunity and 50% boost can reduce the rate to 4.3%. These results indicate that even an imperfect vaccine, when used in combination with other therapies, can be of considerable benefit in preventing MTCT in resource poor countries.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Vacinas contra a AIDS
/
Transmissão Vertical de Doenças Infecciosas
Limite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Newborn
/
Pregnancy
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article