The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element.
Proc Natl Acad Sci U S A
; 106(37): 15756-61, 2009 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-19805223
ABSTRACT
The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3' UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents. Thus, the p53 target Wig-1 is a previously undescribed ARE-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response. Our data reveal a previously undescribed link between the tumor suppressor p53 and posttranscriptional gene regulation via AREs in mRNA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
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Proteínas Nucleares
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Proteínas de Transporte
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Proteína Supressora de Tumor p53
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Estabilidade de RNA
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article