Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.
Bioorg Med Chem Lett
; 19(22): 6413-8, 2009 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-19819692
ABSTRACT
Based on tetrapeptide AVPI, we were able to design and synthesize a new simplified scaffold to inhibit the BIR3 domain of the XIAP protein at low micromolar range. The uncomplicated synthesis and the binding activity of the molecule disclosed here represent an attractive alternative to develop new compounds targeting the protein-protein interaction of XIAP/caspase9.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Relação Estrutura-Atividade
/
Proteínas Inibidoras de Apoptose
/
Proteínas Inibidoras de Apoptose Ligadas ao Cromossomo X
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article