[Alzheimer disease, memory and estrogen]. / Maladie d'Alzheimer, mémoire et estrogènes.
Rev Neurol (Paris)
; 166(4): 377-88, 2010 Apr.
Article
em Fr
| MEDLINE
| ID: mdl-19836813
ABSTRACT
Epidemiological studies of Alzheimer disease have shown a higher prevalence of women. Some data argue for a link between Alzheimer disease and the decrease of estrogen in post-menopausal women. Animal studies have shown a beneficial effect of estrogen on memory with a decrease of amyloid deposition in models of AD, whereas estrogen has a positive effect on BDNF. Six studies have shown a positive effect of estrogen therapy on memory and studies on structural and functional imaging have shown a beneficial effect of estrogens but the largest study on prevention of dementia with estrogens (WHI) showed a deleterious effect. To better understand this paradoxical situation, we reviewed the literature on estrogens, memory and Alzheimer disease. We first discuss the promnesic effect of estrogen on mice and rats, second the neuroprotector effect of estrogen on animal models of Alzheimer disease, and third the available human studies. We hypothesize a link with the time of instauration of the estrogen treatment. Nevertheless this hypothesis remains to be demonstrated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia de Reposição de Estrogênios
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Estrogênios
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Doença de Alzheimer
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Memória
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
Fr
Ano de publicação:
2010
Tipo de documento:
Article