Effect of oral immunization with Aeromonas hydrophila ghosts on protection against experimental fish infection.
Lett Appl Microbiol
; 50(1): 13-7, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19843213
ABSTRACT
AIMS:
To investigate whether oral immunization with Aeromonas hydrophila ghosts (AHG) vaccine can elicit mucosal and systemic immune responses of Carp (Carassius auratus gibelio) compared to conventional formalin-killed bacteria (FKC). METHODS ANDRESULTS:
Fish were fed diets coated with AHG, FKC or phosphate buffered saline (PBS) alone, after immunization, more antigen-specific antibody was significantly detected in serum and intestinal mucus in AHG group than FKC group and PBS group. In addition, after challenged with the parent strain J-1, the survival of bacterial ghost-vaccinated fish was higher than PBS group and FKC group, the relative per cent survival (RPS) being 76.8%, 58.9%, respectively.CONCLUSIONS:
Oral immunization with A. hydrophila ghosts can elicit systemic and mucosal adaptive immune responses and has higher potential to induce protective adaptive immunity than normal vaccine. SIGNIFICANCE AND IMPACT OF THE STUDY Oral immunization with bacterial ghosts is a promising new solution with potential application to prevent diseases in fish.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carpa Dourada
/
Vacinas Bacterianas
/
Infecções por Bactérias Gram-Negativas
/
Aeromonas hydrophila
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Imunidade Adaptativa
/
Doenças dos Peixes
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article