Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins.
Metab Brain Dis
; 24(4): 673-84, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19851851
ABSTRACT
Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Proteínas de Transporte
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Plexo Corióideo
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Homeostase
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Ferro
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article