Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
J Med Chem
; 20(10): 1292-9, 1977 Oct.
Article
em En
| MEDLINE
| ID: mdl-198545
ABSTRACT
A series of novel (8-aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids has been synthesized and evaluated for their ability to mimic the E series prostaglandins in stimulating cAMP formation in the mouse ovary and in binding to the rat kidney plasma prostaglandin receptor. 7-[2-(3-Hydroxyoctyl)-1,1,4-trioxo-3-thiazolidinyl]heptanoic acid markedly stimulates cAMP formation at reasonable pharmacological concentrations and avidly binds to the rat kidney prostaglandin receptor.
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Prostanoicos
/
Ácidos Graxos
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article