Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopy.
Clin Exp Dermatol
; 35(4): 409-16, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-19874320
ABSTRACT
BACKGROUND:
Alopecia areata (AA) is an organ-specific autoimmune disease characterized by folliculotropic T-cell infiltrates around anagen-stage hair follicles. The role of T helper (Th)1 and Th2 cytokines in the pathogenesis of AA have not been established.AIM:
To determine whether serum cytokine profiles define the severity of the AA phenotype or are affected by co-existent atopy.METHODS:
In total, 17 serum cytokines were measured and compared in 269 patients with AA of varying severity with and without atopy and 18 unrelated controls.RESULTS:
Of the 269 patients with AA, 96% had active disease and 54% were atopic. The disease phenotype was transient patchy AA in 27 patients, persistent patchy AA in 89 and alopecia totalis or alopecia universalis in 153. Levels of Th1, interleukin (IL)-1 receptor antagonist (ra) and IL-8 levels were higher in all patients with AA than in controls. IL-1alpha, IL-12 and tumour necrosis factor-alpha levels were higher in patients with AA and atopy than in patients with AA without atopy.CONCLUSIONS:
Increased Th1 serum cytokines (IL-2, IL-12 and interferon-gamma) and IL-1ra levels are associated with AA regardless of disease severity or the presence of atopy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
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Células Th1
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Alopecia em Áreas
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Hipersensibilidade Imediata
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article