Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells.
Eur J Immunol
; 40(1): 225-31, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19877012
ABSTRACT
Micro-RNA (miR) are increasingly recognized as critical regulators of tissue-specific patterns of gene expression. CD4+ T cells lacking miR-155, for example, exhibit bias towards Th2 differentiation, indicating that the absence of individual miR could alter CD4+ T-cell differentiation. We now show that miR-155 is induced upon T-cell activation and that it promotes Th1 differentiation when over-expressed in activated CD4+ T cells. Antagonism of miR-155 leads to induction of IFN-gamma receptor alpha-chain (IFN-gammaRalpha), and a functional miR-155 target site is identified within the 3' untranslated region of IFN-gammaRalpha. These results identify IFN-gammaRalpha as a second miR-155 target in T cells and suggest that miR-155 contributes to Th1 differentiation in CD4+ T cells by inhibiting IFN-gamma signaling.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
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Transdução de Sinais
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MicroRNAs
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Receptor de Interferon alfa e beta
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article