N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
Bioorg Med Chem Lett
; 19(24): 6952-6, 2009 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-19879755
The structural modification of a series of [3.3.1] bicyclic sulfonamide based gamma-secretase inhibitors is described. Appropriate substitution on the bicyclic scaffold provides a significant increase in the metabolic stability of the compounds resulting in an improved in vivo metabolic profile.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Sulfonamidas
/
Compostos Bicíclicos com Pontes
/
Secretases da Proteína Precursora do Amiloide
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article