Anticancer activities of artemisinin and its bioactive derivatives.
Expert Rev Mol Med
; 11: e32, 2009 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-19883518
Artemisinin, a sesquiterpene lactone derived from the sweet wormwood plant Artemisia annua, and its bioactive derivatives exhibit potent anticancer effects in a variety of human cancer cell model systems. The pleiotropic response in cancer cells includes growth inhibition by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. These effects of artemisinin and its derivatives result from perturbations of many cellular signalling pathways. This review provides a comprehensive discussion of these cellular responses, and considers the ramifications for the potential development of artemisinin-based compounds in anticancer therapeutic and preventative strategies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
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Artemisininas
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Proteínas Reguladoras de Apoptose
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Anti-Infecciosos
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Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article