[Molecular genetic and bacteriological methods for the diagnosis of multidrug resistant M. tuberculosis].
Tuberk Biolezni Legkih
; (9): 32-5, 2009.
Article
em Ru
| MEDLINE
| ID: mdl-19886013
ABSTRACT
For the early diagnosis of multidrug resistant tuberculosis, 67 sputum samples obtained from primary patients with different clinical forms of pulmonary tuberculosis were examined by the molecular genetic test using the TB-Biochip test system. Having a high sensitivity and specificity, the molecular genetic test for determining the drug sensitivity of Mycobacterium tuberculosis substantially accelerates its diagnosis (2-3 days) before the real-time mode of a patient's admission to the clinic. The method allows identification of mutations in the rpoB (resistance to R), katG, inhG, and ahpC (resistance to H) genes, which permits timely correction of performed specific treatment.
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Base de dados:
MEDLINE
Assunto principal:
Escarro
/
DNA Bacteriano
/
Análise Mutacional de DNA
/
Tuberculose Resistente a Múltiplos Medicamentos
/
Mycobacterium tuberculosis
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Ano de publicação:
2009
Tipo de documento:
Article