Synthesis and in vivo evaluation of 3-substituted gababutins.
Bioorg Med Chem Lett
; 20(1): 362-5, 2010 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-19897364
ABSTRACT
A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the alpha2delta calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo models of pain and anxiety.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ansiolíticos
/
Ácidos Cicloexanocarboxílicos
/
Ciclopentanos
/
Ácido gama-Aminobutírico
/
Aminas
/
Aminoácidos
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article