Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete.
J Nat Prod
; 72(12): 2120-4, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19921834
ABSTRACT
Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)-5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Isoquinolinas
/
Antineoplásicos
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article